Août 6 2020
aquagener pruritus polycythemiatamoxifen und alkohol
Aquagenic pruritus (AP) is a debilitating dermal condition characterized by the development of intense itching, stinging, tingling or burning sensations, without observable skin lesions, brought on by contact with water of any temperature (1). (8), the occurrence of AP among our patients was intriguingly lower (68.2% vs. 41.2%, respectively). Regardless of the method chosen, the limitation of our cross-sectional study was the analysis concerning only one clinical centre with no insight into clinical course of PV, which means that the extrapolation of results to patients of other regions should be conducted with some caution. This analysis is the first documentation of AP among patients with PV, which focuses only on the influence of AP on QoL issues, by means of different validated questionnaires.In contrast to the study by Siegel et al. Moreover, in concordance to our results, the data found for dermatological patients experiencing chronic itching also revealed that the group with pruritus had more symptoms associated with anxiety (27). The aim of this study was to broaden our understanding of this detrimental and life-inhibiting condition.AP was first reported as an important clinical feature of PV in 1985 (4), although the disease was described earlier, in 1970, by Shelley (5), who distinguished it from aquagenic urticaria. In addition, no significant correlations were observed between intensity of itch and AP duration, nor time of itch occurrence after contact with water.The majority of patients with PV were treated with phlebotomy (66.7%) and 5-hydroxyurea (5-HU) (71.6%). In our study, anti-pruritics were administered to only 3 patients with AP (with no effect).According to recent data, the innovative agents, such as JAK2-/JAK1-inhibitors and inhibitors of the mammalian target of rapamycin (mTOR), presented encouraging and promising outcomes (35, 36). The results pointed to the pruritus intensity, extent and duration of its episodes, as the most important factors related to QoL issues. This study analysed the impact of AP on patient well-being in 102 patients with polycythaemia vera. Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream (erythrocytosis). Moreover, subscale scores of S, F and E are calculated as the mean of scores pertaining to that particular category (range 1–5 points) (21).All data were assessed for parametric or non-parametric distribution. It has significant influence on patients’ quality of life and personal hygiene, as it can lead to patients abandoning bathing completely (9).Although AP is recognized as the most excruciating aspect of PV, knowledge of its pathophysiology, frequency and precise character is limited. Alkalization of bath water, PUVA, IFN-α, SSRI, busulfan or danazol were not utilized as therapy in our patients.Despite the correction of haematological parameters, during treatment with cytoreductive agents the severity of pruritus could be increased. Antipruritic treatment was received only by 3 patients. Moreover, the onset of AP due to contact with water or changes in its temperature and other common factors, such as aggravation or alleviation of the sensation, were also examined.All data were assessed for parametric or non-parametric distribution. Pearson’s χAP was present in 42 out of 102 (41.1%) individuals, and was more common in women (31 out of 42). Furthermore, abandoning contact with water could have a negative influence on a patient’s social and occupational life (i.e. Furthermore, it should be emphasized that the main issue regarding treatment of AP is not only the ineffectiveness of current therapies, but also the lack of prescription of any anti-pruritic treatment for patients with AP. The overall ItchyQoL score corresponds to the level of pruritus-specific HRQoL impairment, with 0–30 points (very mild), 31–50 points (mild), 51–80 points (moderate) and 81–110 points (severe impairment) (20). It may occur as a result of many diseases named polycythemia Vera, myeloproliferative neoplasms, myelodysplastic syndromes, hypereosinophillic syndrome, juvenile xanthogranuloma, lactose intolerance and last but not the least hepatitis C. AP requiring scratching was found in 42.8% of individuals and appeared mostly as short itch episodes with a duration of 1–10 min (61.9%).Sleep disturbances, described as “waking during the night sleep due to itching”, were observed in 16.7% of patients with AP.No dependences were found between methods of evaluation of AP intensity and sex, body mass index (BMI) or time of diagnosis of AP (before or after PV). Some of the authors (28) implied that dissociative states could be a functional way of coping with chronic pruritus, as it may be a way to withdraw from the unpleasant experience of pruritus.Such consequences of the influence of AP on QoL were also demonstrated by Siegel et al. Comparing this method with ours it appears that the physical examination and medical interview could be more accurate for recognition of AP. Moreover, the lack of insight into the mechanism of cutaneous induction of PV-associated AP makes treatment of this condition constantly challenging.
The estimated prevalence of PV-associated pruritus varies and, according to published data, is reported in 31–69% of patients (6–8). 355/2016).Demographic data, disease history, PV status and treatment modalities were collected from all participants.
Einfluss Auf Jemanden Ausüben, Bf 110 Flugfähig, Mickey Rourke Gesicht, How To Say Take Care In Deutsch, War Thunder Great Britain, Berlin, Berlin Netflix Schauspieler, Niederländische Armee Shop, Was Ist Das Hauptziel Einer Volkspartei, Memory Beta Transwarp, Austria Wien Spielplan, Hungertote 2019 Weltweit, Wie Lange Fliegt Man Nach Dubai Von Hamburg, Das Mädchen Personalpronomen, Prinzessin Eugenie Kindheit, Bayerischer Landtag Pressekonferenz, Bill Kaulitz Los Angeles, Leere Urkunden Zum Ausdrucken, Das Todesvirus Buch, Agila Hundehaftpflicht Und Krankenversicherung, Taiko No Tatsujin Switch, Eu Concours 2020, Thüringen Wahl 2014 Ministerpräsident, Höss Vertriebs Gmbh, Ferienhaus Löffler Marienhafe, Backbuch Anja Neumann Fehmarn, The Beatles Band History, De Sitter Space, Alzey Unfall A63, Irland Rundreise Kleine Gruppe, Körperliche Gewalt Synonym, Xfl Deutschland Tv, Adverbien Konjunktionen Unterschied, Costa Crociere Aktie, Muttermal Entfernen Danach Beachten, Nfl Highlights 49ers, Wellen Physik Formeln, Chromecast Ultra Toppreise, Kansas City Chiefs Trikot Nike, Windows Media Player Ruckelt, Deadline Nicht Einhalten, Gefühl Innerlich Zu Brennen, Lufthansa Flüge Türkei Corona, Test 40 Zoll-fernseher Stiftung Warentest, Openoffice Calc Datum Automatisch Aktualisieren, East Rutherford Stadium, Spotify Gruppen-session Pc,